Costly Mistakes: Translational Infidelity and Protein Homeostasis
نویسندگان
چکیده
Protein misfolding is increasingly being recognized as a key process in organismal health and disease. Drummond and Wilke (2008) show that misfolding caused by mistakes during the translation of RNA into proteins (mistranslation) also results in a strong selection pressure to optimize translational fidelity, especially for proteins that are highly expressed.
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عنوان ژورنال:
- Cell
دوره 134 شماره
صفحات -
تاریخ انتشار 2008